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Epigenetic inheritance of dna methylation limits activation-induced expression of foxp3 in conventional human cd25-cd4+ t cells
The transcription factor forkhead box P3 (FOXP3 in humans; Foxp3 in mice) controls the development and function of regulatory T cells (Treg). In mice, CD4+CD25– T cells do not express Foxp3 following TCR activation. Whether FOXP3 is a common activation-induced molecule in human T cells—hence not Treg restricted—is

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